インドール誘導体の合成

シアニン系の蛍光色素にはインドール骨格が含まれていて、新成化学では自主研究に関連して数多くのインドール化合物の合成実績があります。

市販のインドールから誘導するケース、インドール骨格の構築等、多数実績があります。

Fischer Indole Synthesis

弊社では最近、Cyanine系蛍光色素の合成に力を入れているため合成実績の多くはFischer法ですが他にも様々なアプローチの合成経験が多数あり、最適な方法を選択することでご希望の構造を合成できると考えております。

Bischler Indole Synthesis

Bishler-Mohlau Indole Synthesis

Nenitzescu 5-Hydrozyindole Synthesis



Hemetsberger-Knittel Indole synthesis

Nenitzescu Indole Synthesis

Saegusa-Ito Indole Synthesis

Gassman Indole Synthesis

Hinsberg-Stolle Indole-Oxindole Synthesis



Bartoli Indole Synthesis

Batcho-Leimgruber Indole synthesis

Hegedus Indole synthesis



Mori-Ban Indole Synthesis

Reissert Indole Synthesis

Walser Indole Synthesis

Madelung Indole Synthesis


 
SCHEM No. Structure Compound Name Price (JPY) Purity Stock(mg)
06396

AADIS7-PEG13-COOH

133,000/0.1mg>95%0.3
04720

Cy5(1-Hex-CONH-PEG13-COOtBu 8,8-diMe 1'-Me 8',8'-diMe)

66,600/0.1mg>90%1.5
06518

Cy5(1-Hex-COOH 5-SO3H 8,8-diMe 1'-Et 5'-SO3H 8'-Me 8'-PEG11-OMe

68,800/0.1mg>90%0
06069

TMSI-PEG10-OH

68,800/0.1mg>95%0.1
06068

TMSI-PEG10-OTrt

63,400/0.2mg>95%9.0
06295

TMSI-PEG8-OH

64,000/0.7mg>95%12.8
06516

Cy5(1-Hex-COOH 5-SO3H 8-Me 8-Pr-SO3H 1'-PEG6-OMe 5'-SO3H 8'-Me 8'-Pr-SO3H)

68,800/0.1mg>90%0
06432

1-(5-carboxypentyl)-2-[(E,3E)-3-[1-[2-(2-methoxyethoxy)ethyl]-3-methyl-5-sulfo-3-(3-sulfopropyl)indolin-2-ylidene]prop-1-enyl]-3-methyl-3-(3-sulfopropyl)indol-1-ium-5-sulfonate

68,800/0.1mg>95%0
06417

Cy7(1-Hex-COOH 5-SO3H 8-Me 8-Pr-SO3H 1'-PEG6-OMe 5'-SO3H 8'-Me 8'-Pr-SO3H)

68,800/0.1mg>95%0
06426

Cy7(1-Hex-COOH 5-SO3H 8-Me 8-Pr-SO3H 1'-PEG5-OMe 5'-SO3H 8'-Me 8'-Pr-SO3H)

68,800/0.1mg>95%0
06419

Cy5(1-Hex-COOH 5-SO3H 8-Me 8-Pr-SO3H 1'-PEG5-OMe 5'-SO3H 8'-Me 8'-Pr-SO3H)

68,800/0.1mg>90%0
06511

3-(5-carboxypentyl)-1-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethyl]-2-[(1E,3E,5E)-5-[3-(2-methoxyethyl)-1-methyl-1-(3-sulfopropyl)benzo[e]indol-2-ylidene]penta-1,3-dienyl]-1-methyl-8-sulfo-benzo[e]indol-3-ium-6-sulfonate

68,800/0.1mg>90%0
06509

1-(5-carboxypentyl)-2-[(E,3Z)-3-[1-ethyl-3-[2-(2-methoxyethoxy)ethyl]-3-methyl-5-sulfo-indolin-2-ylidene]prop-1-enyl]-3-[2-(2-methoxyethoxy)ethyl]-3-methyl-indol-1-ium-5-sulfonate

68,800/0.1mg>95%0
06434

2-[(E,3Z)-3-[1,3-bis[2-(2-methoxyethoxy)ethyl]-3-methyl-5-sulfo-indolin-2-ylidene]prop-1-enyl]-1-[2-[2-(2-carboxyethoxy)ethoxy]ethyl]-3-[2-(2-methoxyethoxy)ethyl]-3-methyl-indol-1-ium-5-sulfonate

68,800/0.1mg>95%0
06433

Cy5(1-Hex-COOH 5-SO3H 8-Me 8-PEG4-OMe 1'-Et 5'-SO3H 8'-Me 8'-PEG3-OMe)

68,800/0.1mg>90%0
06422

Cy5(1-Hex-COOH 5-SO3H 8-Me 8-Pr-SO3H 1'-PEG4-OMe 5'-SO3H 8'-Me 8'-Pr-SO3H)

68,800/0.1mg>90%0
06293

TMSI-PEG4-Pr-COOH

64,000/0.7mg>95%0
06062

Cy7(1-PEG4-COOH 5-SO3H 8,8-diMe 1'-Me 5'-SO3H 8',8'-diMe)

105,500/0.1mg>95%0.1
06059

AADIS7-PEG4-COOMe

133,000/0.1mg>95%3.9
06009

Cy7(1-PEG4-COOMe 5-SO3H 8,8-diMe 1'-Me 5'-SO3H 8',8'-diMe)

105,500/0.1mg>95%0
05970

Cy7(1-HexCOOH 5-SO3H 8,8-diMe 1'-PEG4-OH 8',8'-diMe)

68,800/0.1mg>95%0
05948

TMSI-PEG4-OH

68,800/0.2mg>95%15.7
05075

AADIS7-PEG3-OAc

65,700/0.4mg>95%3.0
03545

TMSI-PEG4-COOMe

68,800/0.1mg>95%1.6
06512

3-(5-carboxypentyl)-1-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethyl]-2-[(1E,3E,5E)-5-[3-(2-methoxyethyl)-1-methyl-1-(3-sulfopropyl)benzo[e]indol-2-ylidene]penta-1,3-dienyl]-1-methyl-8-sulfo-benzo[e]indol-3-ium-6-sulfonate

68,800/0.1mg>90%0
06431

Cy7(1-Hex-COOH 5-SO3H 8-Me 8-Pr-SO3H 1'-PEG3-OMe 5'-SO3H 8'-Me 8'-Pr-SO3H)

68,800/0.1mg>95%0
06430

Cy5(1-Hex-COOH 5-SO3H 8-Me 8-Pr-SO3H 1'-PEG4-OMe 5'-SO3H 8'-Me 8'-Pr-SO3H)

68,800/0.1mg>90%0
06425

Cy7(1-Hex-COOH 5-SO3H 8-Me 8-Pr-SO3H 1'-PEG3-OMe 5'-SO3H 8'-Me 8'-Pr-SO3H)

68,800/0.1mg>95%0
06423

Cy7(1-Hex-COOH 5-SO3H 8-Me 8-Pr-SO3H 1'-PEG3-OMe 5'-SO3H 8'-Me 8'-Pr-SO3H)

68,800/0.1mg>95%0
06421

1-(5-carboxypentyl)-2-[(E,3E)-3-[1-[2-[2-(2-methoxyethoxy)ethoxy]ethyl]-3-methyl-5-sulfo-3-(3-sulfopropyl)indolin-2-ylidene]prop-1-enyl]-3-methyl-3-(3-sulfopropyl)indol-1-ium-5-sulfonate

68,800/0.1mg>95%0
06420

(3R)-1-(5-carboxypentyl)-2-[(E,3E)-3-[(3S)-1-[2-[2-(2-methoxyethoxy)ethoxy]ethyl]-3-methyl-5-sulfo-3-(3-sulfopropyl)indolin-2-ylidene]prop-1-enyl]-3-methyl-3-(3-sulfopropyl)indol-1-ium-5-sulfonate

68,800/0.1mg>95%0
06061

Cy7(1-Hex-COOH 5-SO3H 8,8-diMe 1'-PEG3-OAc 5'-SO3H 8',8'-diMe)

105,500/0.1mg>95%0.1
05146

TMSI-PEG3-OH

68,800/0.1mg>95%89.4
06515

2-[(E,3E)-3-[3,3-dimethyl-5-sulfo-1-[2-[2-(4-sulfobutoxy)ethoxy]ethyl]indolin-2-ylidene]prop-1-enyl]-3,3-dimethyl-1-[2-[2-(4-sulfobutoxy)ethoxy]ethyl]indol-1-ium-5-sulfonate

68,800/0.1mg>95%0
06513

3-[2-[(1E,3E,5Z)-5-[3,3-dimethyl-5-sulfo-1-(3-sulfopropyl)indolin-2-ylidene]penta-1,3-dienyl]-3-[5-[2-(2-hydroxyethoxy)ethylamino]-5-oxo-pentyl]-3-methyl-5-sulfo-indol-1-ium-1-yl]propane-1-sulfonate

68,800/0.1mg>95%0
06510

Cy7(1-Pr-SO3H 5-SO3H 8-Me 8-Hex-CONH-PEG2-OMe 1'-Pr-SO3H 5'-SO3H 8',8'-diMe)

68,800/0.1mg>95%0
06440

Cy7(1-HexCOOH 5-SO3H 8-Me 8-Pr-SO3H 1'-PEG2-OMe 8'-Me 8'-Pr-SO3H)

68,800/0.1mg>95%0
06439

Cy5(1-Hex-COOH 5-SO3H 8-Me 8-Pr-SO3H 1'-PEG2-OMe 5'-SO3H 8'-Me 8'-Pr-SO3H)

68,800/0.1mg>90%0
06460

TMI-PEG1-COOtBu

64,900/7.5mg>95%272.0
06459

TMI-PEG1-COOEt

64,900/7.5mg>95%258.2
06523

Cy7(1-PEG4-COOH 5-SO3H 8,8-di-Me 1'-PEG4-COOH 5'-SO3H 8',8'-diMe)(4-Et-SO3H)

68,800/0.1mg>95%0
06522

Cy7(1-HexCOOH 5-SO3H 8-Me 8-Pr-SO3H 1'-PEG4-OMe 5'-SO3H 8'-Me 8'-Pr-SO3H)

68,800/0.1mg>95%0
06521

1-(5-carboxypentyl)-2-[(E,3E)-3-[1-[2-(2-methoxyethoxy)ethyl]-3-methyl-5-sulfo-3-(3-sulfopropyl)indolin-2-ylidene]prop-1-enyl]-3-methyl-3-(3-sulfopropyl)indol-1-ium-5-sulfonate

68,800/0.1mg>95%0
06520

Cy5(1-PEG4-Pr-COOH 5-SO3H 8-Me 8-PEG4-OMe 1'-PE4-OMe 5'-SO3H 8'-Me 8'-PEG4-OMe)

68,800/0.1mg>90%0
06519

Cy7(1-HexCOOH 5-SO3H 8-Me 8-PEG4-OMe 1'-Et 5'-SO3H 8'-Me 8'-PEG4-OMe)

68,800/0.1mg>95%0
06517

1-(4-aminobutyl)-2-[(1E,3E,5E)-5-[1-(5-carboxypentyl)-3,3-dimethyl-indolin-2-ylidene]penta-1,3-dienyl]-3,3-dimethyl-indol-1-ium-5-sulfonate

133,000/0.1mg>95%0
06514

1-ethyl-2-[(E,3E)-3-[1-[6-(2-hydroxyethoxy)-6-oxo-hexyl]-3,3-dimethyl-5-sulfo-indolin-2-ylidene]prop-1-enyl]-3,3-dimethyl-indol-1-ium-5-sulfonate

68,800/0.1mg>95%0
06446

3-[2-[2-[(2E)-2-[(E)-3-[3,3-dimethyl-1-[2-[2-(3-sulfopropoxy)ethoxy]ethyl]indol-1-ium-2-yl]prop-2-enylidene]-3,3-dimethyl-indolin-1-yl]ethoxy]ethoxy]propane-1-sulfonic acid

68,800/0.1mg>95%0
06438

Cy7(1-HexCOOH 8,8-diMe 1'-Me 8',8'-diMe)(3,5-Pr-cyclic)

133,000/0.1mg>95%0
06418

Cy7(1-PEG5-COOH 5-SO3H 8-Me 8-PEG4-OMe 1'-PEG4-OMe 5'-SO3H 8'-Me 8'-PEG4-OMe)

68,800/0.1mg>95%0
06416

1-(5-carboxypentyl)-2-[(E,3E)-3-[1-[2-(2-methoxyethoxy)ethyl]-3-methyl-5-sulfo-3-(3-sulfopropyl)indolin-2-ylidene]prop-1-enyl]-3-methyl-3-(3-sulfopropyl)indol-1-ium-5-sulfonate

68,800/0.1mg>95%0
06337

AADI7-Et-OH

64,000/0.7mg>95%399.4
06336

TMI-Et-OH

inquire>90%2,799.9
06297

AADIS5-Et-OAc

68,800/0.2mg>95%8.0
06296

Cy5(1-Hex-COOH 5-SO3H 8,8-diMe 1'-Pr-SO3H 5'-SO3H 8',8'-diMe)

105,500/0.1mg>90%0.9
06114

AADIS7-Et-SO3H

68,800/0.1mg>80%7.6
06035

TMSI-Et-SO3H

65,700/0.4mg>80%20.4
05969

AADIS5-Hex-COOH

64,000/0.7mg>95%1.0
05959

AADIS5-Me

68,800/0.2mg>95%9.3
05954

AADIS7-Hex-COOH

68,800/0.1mg>95%0.1
05945

TMSI-acetoxyacetic acid

68,800/0.1mg>95%5.3
05944

TMSI-Me

inquire>95%3.3
05941

AADIS5-HexCOOH

64,000/0.7mg>95%31.2
05364

AADIS5-Et-SO3H

105,500/0.1mg>95%2.4
05147

Sulfo Cy3-diamine

68,800/0.2mg>95%5.0
05142

TMSI-Et-OH

66,300/2.5mg>95%325.6
05141

TMSI-acetic acid

63,400/0.2mg>95%13.3
05132

TMSI-Et-NH2

68,800/5mg>95%22.7
05072

AADIS7-Me

63,400/0.2mg>95%1.7
04136

TMSI-Hex-COOH

inquire>90%740.6
04132

DMSI(3-Hex-COOH)

68,800/5mg>90%525.4
03607

TMSI-K salt

inquire>90%3,225.9
02837

4-(4-methoxyphenyl)-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]indole

68,100/0.2mg>80%750.0
02834

1,2,3,4-tetrahydrocyclopent[b] indole

inquire>80%1.0
01980

Cy3-halolinker

63,400/0.2mg>95%0.1


オキシインドールの合成も対応可能です。

SCHEM No. Structure Compound Name Price (JPY) Purity Stock(mg)
04937

3-Bromo-2,2-bis(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanol, O-triphenylmethyl

76,000/0.1mg>95%50.0
03390

Indigo

63,400/50mg>90%31.8

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