Shinsei Chemical's unique HaloTag HaloLinker (HaloTag HaloLinker).

We have extensive experience in the synthesis of halo-linkers and fluorescent-labelled compounds with Tag combined with various fluorescent dyes using our unique synthetic methods.

Wikipedia

The most commonly used HaloTag has the following structure and reacts with NHS of various fluorescent dyes to synthesise the desired halo-linked fluorescent dye,

but the halo-linker part tends to react with amino groups and there is some concern about storage stability, so a time-consuming preparation from the precursor amino protector is employed.


SCHEM No. Structure Compound Name Price (JPY) Purity Stock(mg)
06673

NH2-PEG23-O-HexCl

87,600/0.2mg>90%0
08450

TrtNH-PEG22-O-HexCl

65,400/2.5mg>90%0
06672

NH2-PEG22-O-HexCl

95,000/2.5mg>90%0
08449

TrtNH-PEG21-O-HexCl

64,900/0.6mg>90%0
06671

NH2-PEG21-O-HexCl

83,600/0.3mg>90%0
08448

TrtNH-PEG20-O-HexCl

64,900/0.6mg>95%0
06670

NH2-PEG20-O-HexCl

83,600/0.3mg>90%0
08447

TrtNH-PEG19-O-HexCl

76,300/2.5mg>95%0
06669

NH2-PEG19-O-HexCl

83,600/0.6mg>90%0
08446

TrtNH-PEG18-O-HexCl

64,900/0.6mg>95%0
06668

NH2-PEG18-O-HexCl

83,600/0.3mg>90%0
08445

TrtNH-PEG17-O-HexCl

64,900/0.6mg>95%0
06667

NH2-PEG17-O-HexCl

83,600/0.3mg>90%0
08444

TrtNH-PEG16-O-HexCl

64,900/0.6mg>95%0
06666

NH2-PEG16-O-HexCl

83,600/0.3mg>90%0
08443

TrtNH-PEG15-O-HexCl

64,900/0.6mg>95%0
06665

NH2-PEG15-O-HexCl

83,600/0.3mg>90%0
08442

TrtNH-PEG14-O-HexCl

64,900/0.6mg>95%0
06664

NH2-PEG14-O-HexCl

83,600/0.3mg>90%0
08441

TrtNH-PEG13-O-HexCl

76,300/2.5mg>95%0
06663

NH2-PEG13-O-HexCl

83,600/0.6mg>90%0
04704

NH2-PEG13-CONH-PEG2-O-HexCl

84,900/0.1mg>90%0.1
04703

Boc-NH-PEG13-CONH-PEG2-O-HexCl

66,700/0.7mg>95%2.0
08440

TrtNH-PEG12-O-HexCl

64,900/0.6mg>95%0
06662

NH2-PEG12-O-HexCl

83,600/0.3mg>90%0
08439

TrtNH-PEG11-O-HexCl

64,900/0.6mg>95%0
06661

NH2-PEG11-O-HexCl

83,600/0.3mg>90%0
08438

TrtNH-PEG10-O-HexCl

68,500/25mg>95%0
06660

NH2-PEG10-O-HexCl

84,200/10mg>90%0
06722

TrtNH-PEG9-O-HexCl

68,500/25mg>95%0
06659

NH2-PEG9-O-HexCl

84,200/10mg>90%0
06721

TrtNH-PEG8-O-HexCl

65,400/5mg>95%0
06658

NH2-PEG8-O-HexCl

84,200/2.5mg>90%0
02774

NH2-PEG7-O-HexCl

84,200/2.5mg>95%0
02772

TrtNH-PEG7-O-HexCl

68,100/5mg>95%0.1
06720

TrtNH-PEG6-O-HexCl

65,400/5mg>95%0
06657

NH2-PEG6-O-HexCl

84,200/2.5mg>95%0
06656

NH2-PEG5-O-HexCl

87,300/50mg>95%27.9
06652

TrtNH-PEG5-O-HexCl

84,900/2.5mg>95%0
06719

TrtNH-PEG4-O-HexCl

64,600/75mg>95%3.2
06655

NH2-PEG4-O-HexCl

87,300/50mg>95%21.8
02736

BocNH-PEG4-O-HexCl

84,900/2.5mg>95%14.0
06654

NH2-PEG3-O-HexCl

84,200/5mg>95%0
02735

BocNH-PEG3-O-hex-Cl

64,900/7.5mg>95%0
01927

NH2-PEG2-O-HexCl

84,200/5mg>90%10.1
01574

BocNH-PEG2-O-HexCl

70,000/25mg>90%473.1

 

In addition, it is often the case that the terminal functional group is changed to a carboxyl group by reacting it with a dicarboxylic acid, but there is concern that this may affect the properties of the linker and reduce its performance because of the amide bond between the carboxylic acid and the carboxyl group.

We have experience in the synthesis of terminal carboxylic acid halolinkers that do not involve an amide bond.

Key points for the active ester (NHS).


SCHEM No. Structure Compound Name Price (JPY) Purity Stock(mg)
07140

HexCl-PEG45-COOH

68,800/0.2mg>90%0
07139

HexCl-PEG44-COOH

68,800/0.2mg>90%0
07138

HexCl-PEG43-COOH

68,800/0.2mg>90%0
07137

HexCl-PEG42-COOH

68,800/0.2mg>90%0
07136

HexCl-PEG41-COOH

68,800/0.2mg>90%0
07135

HexCl-PEG40-COOH

68,800/0.2mg>90%0
07134

HexCl-PEG39-COOH

68,800/0.2mg>90%0
07133

HexCl-PEG38-COOH

68,800/0.2mg>90%0
07132

HexCl-PEG37-COOH

64,900/0.3mg>90%0
07131

HexCl-PEG36-COOH

68,800/0.2mg>90%0
07130

HexCl-PEG35-COOH

68,800/0.2mg>90%0
07129

HexCl-PEG34-COOH

68,800/0.2mg>90%0
07128

HexCl-PEG33-COOH

68,800/0.2mg>90%0
07127

HexCl-PEG32-COOH

68,800/0.2mg>90%0
07126

HexCl-PEG31-COOH

68,800/0.2mg>90%0
07125

HexCl-PEG30-COOH

68,800/0.2mg>90%0
07124

HexCl-PEG29-COOH

64,900/0.3mg>90%0
07123

HexCl-PEG28-COOH

64,900/0.3mg>90%0
07122

HexCl-PEG27-COOH

68,800/0.2mg>90%0
07121

HexCl-PEG26-COOH

68,800/0.2mg>90%0
07120

HexCl-PEG25-COOH

68,800/0.2mg>90%0
07109

HexCl-PEG24-COOH

68,800/0.2mg>90%0
07108

HexCl-PEG23-COOH

68,800/0.2mg>90%0
08486

HexCl-PEG22-COOtBu

81,500/2.5mg>90%0
07107

HexCl-PEG22-COOH

76,300/2.5mg>90%0
08485

HexCl-PEG21-COOtBu

80,900/0.6mg>90%0
07106

HexCl-PEG21-COOH

64,900/0.3mg>90%0
08484

HexCl-PEG20-COOtBu

80,900/0.6mg>95%0
07105

HexCl-PEG20-COOH

64,900/0.3mg>95%0
08483

HexCl-PEG19-COOtBu

92,300/2.5mg>95%0
07200

HexCl-PEG19-COOH

64,900/0.6mg>95%0
08482

HexCl-PEG18-COOtBu

80,900/0.6mg>95%0
07099

HexCl-PEG18-COOH

64,900/0.3mg>95%0
08481

HexCl-PEG17-COOtBu

80,900/0.6mg>95%0
07098

HexCl-PEG17-COOH

64,900/0.3mg>95%0
08480

HexCl-PEG16-COOtBu

80,900/0.6mg>95%0
07097

HexCl-PEG16-COOH

64,900/0.3mg>95%0
08479

HexCl-PEG15-COOtBu

80,900/0.6mg>95%0
07096

HexCl-PEG15-COOH

64,900/0.3mg>95%0
08478

HexCl-PEG14-COOtBu

80,900/0.6mg>95%0
07095

HexCl-PEG14-COOH

64,900/0.3mg>95%0
07094

HexCl-PEG13-COOH

64,900/0.6mg>95%1.3
06910

HexCl-PEG13-COOtBu

76,300/2.5mg>95%0
08457

HexCl-PEG12-COOtBu

80,900/0.6mg>95%0
07093

HexCl-PEG12-COOH

64,900/0.3mg>95%0
08456

HexCl-PEG11-COOtBu

80,900/0.6mg>95%0
07092

HexCl-PEG11-COOH

64,900/0.3mg>95%0
06762

HexCl-PEG10-COOH

81,500/10mg>95%4.8
08458

HexCl-PEG9-COOtBu

84,600/25mg>95%0
07091

HexCl-PEG9-COOH

65,400/10mg>95%0
08454

HexCl-PEG8-COOtBu

81,500/5mg>95%0
07090

HexCl-PEG8-COOH

65,400/2.5mg>95%0
08453

HexCl-PEG7-COOtBu

81,500/5mg>95%0
06760

HexCl-PEG7-CONHS

93,000/0.3mg>80%0
06678

HexCl-PEG7-COOH

81,500/2.5mg>95%0
08452

HexCl-PEG6-COOtBu

81,500/5mg>95%0
06759

HexCl-PEG6-CONHS

93,000/0.3mg>80%0
06677

HexCl-PEG6-COOH

81,500/2.5mg>95%0
06758

HexCl-PEG5-CONHS

93,500/5mg>80%0
06674

HexCl-PEG5-COOH

84,600/50mg>95%50.6
06599

HexCl-PEG5-COOtBu

80,600/75mg>95%4.6
06675

HexCl-PEG4-COOH

84,600/50mg>95%0
02740

HexCl-PEG4-CONHS

93,500/5mg>80%0
02738

HexCl-PEG4-COOH

84,600/50mg>95%0
06757

HexCl-PEG3-CONHS

93,000/0.6mg>80%0
06676

HexCl-PEG3-COOH

81,500/5mg>95%0
02739

HexCl-PEG2-CONHS

93,000/0.6mg>80%0
02737

HexCl-PEG2-COOH

81,500/5mg>95%0

 

It is also possible to accommodate a variety of functional groups, such as azide and acetylene.


SCHEM No. Structure Compound Name Price (JPY) Purity Stock(mg)
06713

N3-PEG21-O-HexCl

80,900/0.6mg>90%0
06712

N3-PEG20-O-HexCl

84,900/0.2mg>90%0
06711

N3-PEG19-O-HexCl

84,900/0.2mg>90%0
06710

N3-PEG18-O-HexCl

80,900/0.3mg>90%0
06709

N3-PEG17-O-HexCl

84,900/0.2mg>90%0
06708

N3-PEG16-O-HexCl

84,900/0.2mg>90%0
06699

N3-PEG15-O-HexCl

84,900/0.2mg>90%0
06698

N3-PEG14-O-HexCl

84,900/0.2mg>90%0
06697

N3-PEG13-O-HexCl

84,900/0.2mg>90%0
06692

N3-PEG12-O-HexCl

80,900/0.3mg>95%64.1
06691

N3-PEG11-O-HexCl

84,900/0.2mg>95%0
06690

N3-PEG10-O-HexCl

84,900/0.2mg>95%0
06689

N3-PEG9-O-HexCl

81,500/5mg>95%0
06688

N3-PEG8-O-HexCl

81,500/5mg>95%0
06687

N3-PEG7-O-HexCl

92,300/2.5mg>95%0
06686

N3-PEG6-O-HexCl

92,300/2.5mg>95%0
06685

N3-PEG5-O-HexCl

92,300/2.5mg>95%0
06684

N3-PEG4-O-HexCl

84,600/25mg>95%0
06653

N3-PEG3-O-HexCl

84,600/25mg>95%96.3
06683

N3-PEG2-O-HexCl

81,500/2.5mg>95%0
08477

CC-PEG21-O-HexCl

92,300/2.5mg>90%0
08476

CC-PEG20-O-HexCl

80,900/0.3mg>95%0
08475

CC-PEG19-O-HexCl

80,900/0.3mg>95%0
08474

CC-PEG18-O-HexCl

80,900/0.6mg>95%0
08473

CC-PEG17-O-HexCl

80,900/0.3mg>95%0
08472

CC-PEG16-O-HexCl

80,900/0.3mg>95%0
08471

CC-PEG15-O-HexCl

80,900/0.3mg>95%0
08470

CC-PEG14-O-HexCl

80,900/0.3mg>95%0
08469

CC-PEG13-O-HexCl

80,900/0.3mg>95%0
08468

CC-PEG12-O-HexCl

80,900/0.6mg>95%0
08467

CC-PEG11-O-HexCl

80,900/0.3mg>95%0
08466

CC-PEG10-O-HexCl

80,900/0.3mg>95%0
08465

CC-PEG9-O-HexCl

81,500/10mg>95%0
08464

CC-PEG8-O-HexCl

81,500/10mg>95%0
08463

CC-PEG7-O-HexCl

81,500/2.5mg>95%0
08462

CC-PEG6-O-HexCl

81,500/2.5mg>95%0
08461

CC-PEG5-O-HexCl

81,500/2.5mg>95%0
08460

CC-PEG4-O-HexCl

84,600/50mg>95%0
06680

CC-PEG3-O-HexCl

84,600/50mg>95%0
06681

CC-PEG2-O-HexCl

81,500/5mg>95%0
06682

CC-PEG1-O-HexCl

81,500/10mg>95%0

 

We also have extensive experience in synthesising halo-tagged fluorescent dyes.

SCHEM No. Structure Compound Name Price (JPY) Purity Stock(mg)
05373

Cy5(1-Pr-SO3H 5-SO3H 8-Me 8-Hex-CONH-PEG13-CONH-PEG2-Hex-Cl 1'-Pr-SO3H 5'-SO3H 8',8'-diMe)

133,000/0.1mg>90%0.1
04746

CF660R-PEG13-PEG2-O-HexCl

133,000/0.1mg>95%0.1
02819

CR110-Halolinker

68,800/0.1mg>95%0.3
01979

BODIPY halolinker

105,500/0.1mg>95%0.3
01980

Cy3-halolinker

63,400/0.2mg>95%0.1

In addition to the list above, we have many other synthesis results. The synthesis method has been established, so it can be synthesised in about a week by reacting with inexpensive commercially available fluorescent dyes.

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