Shinsei Chemical's unique HaloTag HaloLinker (HaloTag HaloLinker).
We have extensive experience in the synthesis of halo-linkers and fluorescent-labelled compounds with Tag combined with various fluorescent dyes using our unique synthetic methods.
The most commonly used HaloTag has the following structure and reacts with NHS of various fluorescent dyes to synthesise the desired halo-linked fluorescent dye,
but the halo-linker part tends to react with amino groups and there is some concern about storage stability, so a time-consuming preparation from the precursor amino protector is employed.
| SCHEM No. | Structure | Compound Name | Price (JPY) | Purity | Stock(mg) |
|---|---|---|---|---|---|
| 06673 |  | NH2-PEG23-O-HexCl | 88,400/0.2mg | >90% | 0 |
| 08450 |  | TrtNH-PEG22-O-HexCl | 66,200/2.5mg | >90% | 0 |
| 06672 |  | NH2-PEG22-O-HexCl | 82,200/1mg | >90% | 0 |
| 08449 |  | TrtNH-PEG21-O-HexCl | 63,400/0.5mg | >90% | 0 |
| 06671 |  | NH2-PEG21-O-HexCl | 84,400/0.3mg | >90% | 0 |
| 08448 |  | TrtNH-PEG20-O-HexCl | 63,400/0.5mg | >95% | 0 |
| 06670 |  | NH2-PEG20-O-HexCl | 84,400/0.3mg | >90% | 0 |
| 08447 |  | TrtNH-PEG19-O-HexCl | 63,400/1mg | >95% | 0 |
| 06669 |  | NH2-PEG19-O-HexCl | 82,200/0.5mg | >90% | 0 |
| 08446 |  | TrtNH-PEG18-O-HexCl | 63,400/0.5mg | >95% | 0 |
| 06668 |  | NH2-PEG18-O-HexCl | 84,400/0.3mg | >90% | 0 |
| 08445 |  | TrtNH-PEG17-O-HexCl | 63,400/0.5mg | >95% | 0 |
| 06667 |  | NH2-PEG17-O-HexCl | 84,400/0.3mg | >90% | 0 |
| 08444 |  | TrtNH-PEG16-O-HexCl | 63,400/0.5mg | >95% | 0 |
| 06666 |  | NH2-PEG16-O-HexCl | 84,400/0.3mg | >90% | 0 |
| 08443 |  | TrtNH-PEG15-O-HexCl | 63,400/0.5mg | >95% | 0 |
| 06665 |  | NH2-PEG15-O-HexCl | 84,400/0.3mg | >90% | 0 |
| 08442 |  | TrtNH-PEG14-O-HexCl | 63,400/0.5mg | >95% | 0 |
| 06664 |  | NH2-PEG14-O-HexCl | 84,400/0.3mg | >90% | 0 |
| 08441 |  | TrtNH-PEG13-O-HexCl | 63,400/1mg | >95% | 0 |
| 06663 |  | NH2-PEG13-O-HexCl | 82,200/0.5mg | >90% | 0 |
| 04704 |  | NH2-PEG13-CONH-PEG2-O-HexCl | 85,700/0.1mg | >90% | 0.1 |
| 04703 |  | Boc-NH-PEG13-CONH-PEG2-O-HexCl | 67,500/0.7mg | >95% | 2.0 |
| 08440 |  | TrtNH-PEG12-O-HexCl | 63,400/0.5mg | >95% | 0 |
| 06662 |  | NH2-PEG12-O-HexCl | 84,400/0.3mg | >90% | 0 |
| 08439 |  | TrtNH-PEG11-O-HexCl | 63,400/0.5mg | >95% | 0 |
| 06661 |  | NH2-PEG11-O-HexCl | 84,400/0.3mg | >90% | 0 |
| 08438 |  | TrtNH-PEG10-O-HexCl | 69,300/25mg | >95% | 0 |
| 06660 |  | NH2-PEG10-O-HexCl | 85,000/10mg | >90% | 0 |
| 06722 |  | TrtNH-PEG9-O-HexCl | 69,300/25mg | >95% | 0 |
| 06659 |  | NH2-PEG9-O-HexCl | 85,000/10mg | >90% | 0 |
| 06721 |  | TrtNH-PEG8-O-HexCl | 66,200/5mg | >95% | 0 |
| 06658 |  | NH2-PEG8-O-HexCl | 85,000/2.5mg | >90% | 0 |
| 02774 |  | NH2-PEG7-O-HexCl | 85,000/2.5mg | >95% | 0 |
| 02772 |  | TrtNH-PEG7-O-HexCl | 68,900/5mg | >95% | 0.1 |
| 06720 |  | TrtNH-PEG6-O-HexCl | 66,200/5mg | >95% | 0 |
| 06657 |  | NH2-PEG6-O-HexCl | 85,000/2.5mg | >95% | 0 |
| 06656 |  | NH2-PEG5-O-HexCl | 88,100/50mg | >95% | 27.9 |
| 06652 |  | TrtNH-PEG5-O-HexCl | 85,700/2.5mg | >95% | 0 |
| 06719 |  | TrtNH-PEG4-O-HexCl | 65,400/75mg | >95% | 3.2 |
| 06655 |  | NH2-PEG4-O-HexCl | 88,100/50mg | >95% | 21.8 |
| 02736 |  | BocNH-PEG4-O-HexCl | 85,700/2.5mg | >95% | 14.0 |
| 06654 |  | NH2-PEG3-O-HexCl | 85,000/5mg | >95% | 0 |
| 02735 |  | BocNH-PEG3-O-hex-Cl | 65,700/7.5mg | >95% | 0 |
| 01927 |  | NH2-PEG2-O-HexCl | 85,000/5mg | >90% | 10.1 |
| 01574 |  | BocNH-PEG2-O-HexCl | 70,800/25mg | >90% | 473.1 |
In addition, it is often the case that the terminal functional group is changed to a carboxyl group by reacting it with a dicarboxylic acid, but there is concern that this may affect the properties of the linker and reduce its performance because of the amide bond between the carboxylic acid and the carboxyl group.
We have experience in the synthesis of terminal carboxylic acid halolinkers that do not involve an amide bond.
Key points for the active ester (NHS).
| SCHEM No. | Structure | Compound Name | Price (JPY) | Purity | Stock(mg) |
|---|---|---|---|---|---|
| 07140 |  | HexCl-PEG45-COOH | 69,600/0.2mg | >90% | 0 |
| 07139 |  | HexCl-PEG44-COOH | 69,600/0.2mg | >90% | 0 |
| 07138 |  | HexCl-PEG43-COOH | 69,600/0.2mg | >90% | 0 |
| 07137 |  | HexCl-PEG42-COOH | 69,600/0.2mg | >90% | 0 |
| 07136 |  | HexCl-PEG41-COOH | 69,600/0.2mg | >90% | 0 |
| 07135 |  | HexCl-PEG40-COOH | 69,600/0.2mg | >90% | 0 |
| 07134 |  | HexCl-PEG39-COOH | 69,600/0.2mg | >90% | 0 |
| 07133 |  | HexCl-PEG38-COOH | 69,600/0.2mg | >90% | 0 |
| 07132 |  | HexCl-PEG37-COOH | 65,700/0.3mg | >90% | 0 |
| 07131 |  | HexCl-PEG36-COOH | 69,600/0.2mg | >90% | 0 |
| 07130 |  | HexCl-PEG35-COOH | 69,600/0.2mg | >90% | 0 |
| 07129 |  | HexCl-PEG34-COOH | 69,600/0.2mg | >90% | 0 |
| 07128 |  | HexCl-PEG33-COOH | 69,600/0.2mg | >90% | 0 |
| 07127 |  | HexCl-PEG32-COOH | 69,600/0.2mg | >90% | 0 |
| 07126 |  | HexCl-PEG31-COOH | 69,600/0.2mg | >90% | 0 |
| 07125 |  | HexCl-PEG30-COOH | 69,600/0.2mg | >90% | 0 |
| 07124 |  | HexCl-PEG29-COOH | 65,700/0.3mg | >90% | 0 |
| 07123 |  | HexCl-PEG28-COOH | 65,700/0.3mg | >90% | 0 |
| 07122 |  | HexCl-PEG27-COOH | 69,600/0.2mg | >90% | 0 |
| 07121 |  | HexCl-PEG26-COOH | 69,600/0.2mg | >90% | 0 |
| 07120 |  | HexCl-PEG25-COOH | 69,600/0.2mg | >90% | 0 |
| 07109 |  | HexCl-PEG24-COOH | 69,600/0.2mg | >90% | 0 |
| 07108 |  | HexCl-PEG23-COOH | 69,600/0.2mg | >90% | 0 |
| 08486 |  | HexCl-PEG22-COOtBu | 82,300/2.5mg | >90% | 0 |
| 07107 |  | HexCl-PEG22-COOH | 63,400/1mg | >90% | 0 |
| 08485 |  | HexCl-PEG21-COOtBu | 79,500/0.5mg | >90% | 0 |
| 07106 |  | HexCl-PEG21-COOH | 65,700/0.3mg | >90% | 0 |
| 08484 |  | HexCl-PEG20-COOtBu | 79,500/0.5mg | >95% | 0 |
| 07105 |  | HexCl-PEG20-COOH | 65,700/0.3mg | >95% | 0 |
| 08483 |  | HexCl-PEG19-COOtBu | 79,500/1mg | >95% | 0 |
| 07200 |  | HexCl-PEG19-COOH | 63,400/0.5mg | >95% | 0 |
| 08482 |  | HexCl-PEG18-COOtBu | 79,500/0.5mg | >95% | 0 |
| 07099 |  | HexCl-PEG18-COOH | 65,700/0.3mg | >95% | 0 |
| 08481 |  | HexCl-PEG17-COOtBu | 79,500/0.5mg | >95% | 0 |
| 07098 |  | HexCl-PEG17-COOH | 65,700/0.3mg | >95% | 0 |
| 08480 |  | HexCl-PEG16-COOtBu | 79,500/0.5mg | >95% | 0 |
| 07097 |  | HexCl-PEG16-COOH | 65,700/0.3mg | >95% | 0 |
| 08479 |  | HexCl-PEG15-COOtBu | 79,500/0.5mg | >95% | 0 |
| 07096 |  | HexCl-PEG15-COOH | 65,700/0.3mg | >95% | 0 |
| 08478 |  | HexCl-PEG14-COOtBu | 79,500/0.5mg | >95% | 0 |
| 07095 |  | HexCl-PEG14-COOH | 65,700/0.3mg | >95% | 0 |
| 07094 |  | HexCl-PEG13-COOH | 63,400/0.5mg | >95% | 1.3 |
| 06910 |  | HexCl-PEG13-COOtBu | 63,400/1mg | >95% | 0 |
| 08457 |  | HexCl-PEG12-COOtBu | 79,500/0.5mg | >95% | 0 |
| 07093 |  | HexCl-PEG12-COOH | 65,700/0.3mg | >95% | 0 |
| 08456 |  | HexCl-PEG11-COOtBu | 79,500/0.5mg | >95% | 0 |
| 07092 |  | HexCl-PEG11-COOH | 65,700/0.3mg | >95% | 0 |
| 06762 |  | HexCl-PEG10-COOH | 82,300/10mg | >95% | 4.8 |
| 08458 |  | HexCl-PEG9-COOtBu | 85,400/25mg | >95% | 0 |
| 07091 |  | HexCl-PEG9-COOH | 66,200/10mg | >95% | 0 |
| 08454 |  | HexCl-PEG8-COOtBu | 82,300/5mg | >95% | 0 |
| 07090 |  | HexCl-PEG8-COOH | 66,200/2.5mg | >95% | 0 |
| 08453 |  | HexCl-PEG7-COOtBu | 82,300/5mg | >95% | 0 |
| 06760 |  | HexCl-PEG7-CONHS | 93,800/0.3mg | >80% | 0 |
| 06678 |  | HexCl-PEG7-COOH | 82,300/2.5mg | >95% | 0 |
| 08452 |  | HexCl-PEG6-COOtBu | 82,300/5mg | >95% | 0 |
| 06759 |  | HexCl-PEG6-CONHS | 93,800/0.3mg | >80% | 0 |
| 06677 |  | HexCl-PEG6-COOH | 82,300/2.5mg | >95% | 0 |
| 06758 |  | HexCl-PEG5-CONHS | 94,300/5mg | >80% | 0 |
| 06674 |  | HexCl-PEG5-COOH | 85,400/50mg | >95% | 50.6 |
| 06599 |  | HexCl-PEG5-COOtBu | 81,400/75mg | >95% | 4.6 |
| 06675 |  | HexCl-PEG4-COOH | 85,400/50mg | >95% | 0 |
| 02740 |  | HexCl-PEG4-CONHS | 94,300/5mg | >80% | 0 |
| 02738 |  | HexCl-PEG4-COOH | 85,400/50mg | >95% | 0 |
| 06757 |  | HexCl-PEG3-CONHS | 91,600/0.5mg | >80% | 0 |
| 06676 |  | HexCl-PEG3-COOH | 82,300/5mg | >95% | 0 |
| 02739 |  | HexCl-PEG2-CONHS | 91,600/0.5mg | >80% | 0 |
| 02737 |  | HexCl-PEG2-COOH | 82,300/5mg | >95% | 0 |
It is also possible to accommodate a variety of functional groups, such as azide and acetylene.
| SCHEM No. | Structure | Compound Name | Price (JPY) | Purity | Stock(mg) |
|---|---|---|---|---|---|
| 06713 |  | N3-PEG21-O-HexCl | 79,500/0.5mg | >90% | 0 |
| 06712 |  | N3-PEG20-O-HexCl | 85,700/0.2mg | >90% | 0 |
| 06711 |  | N3-PEG19-O-HexCl | 85,700/0.2mg | >90% | 0 |
| 06710 |  | N3-PEG18-O-HexCl | 81,800/0.3mg | >90% | 0 |
| 06709 |  | N3-PEG17-O-HexCl | 85,700/0.2mg | >90% | 0 |
| 06708 |  | N3-PEG16-O-HexCl | 85,700/0.2mg | >90% | 0 |
| 06699 |  | N3-PEG15-O-HexCl | 85,700/0.2mg | >90% | 0 |
| 06698 |  | N3-PEG14-O-HexCl | 85,700/0.2mg | >90% | 0 |
| 06697 |  | N3-PEG13-O-HexCl | 85,700/0.2mg | >90% | 0 |
| 06692 |  | N3-PEG12-O-HexCl | 81,800/0.3mg | >95% | 64.1 |
| 06691 |  | N3-PEG11-O-HexCl | 85,700/0.2mg | >95% | 0 |
| 06690 |  | N3-PEG10-O-HexCl | 85,700/0.2mg | >95% | 0 |
| 06689 |  | N3-PEG9-O-HexCl | 82,300/5mg | >95% | 0 |
| 06688 |  | N3-PEG8-O-HexCl | 82,300/5mg | >95% | 0 |
| 06687 |  | N3-PEG7-O-HexCl | 79,500/1mg | >95% | 0 |
| 06686 |  | N3-PEG6-O-HexCl | 79,500/1mg | >95% | 0 |
| 06685 |  | N3-PEG5-O-HexCl | 79,500/1mg | >95% | 0 |
| 06684 |  | N3-PEG4-O-HexCl | 85,400/25mg | >95% | 0 |
| 06653 |  | N3-PEG3-O-HexCl | 85,400/25mg | >95% | 96.3 |
| 06683 |  | N3-PEG2-O-HexCl | 82,300/2.5mg | >95% | 0 |
| 08477 |  | CC-PEG21-O-HexCl | 79,500/1mg | >90% | 0 |
| 08476 |  | CC-PEG20-O-HexCl | 81,800/0.3mg | >95% | 0 |
| 08475 |  | CC-PEG19-O-HexCl | 81,800/0.3mg | >95% | 0 |
| 08474 |  | CC-PEG18-O-HexCl | 79,500/0.5mg | >95% | 0 |
| 08473 |  | CC-PEG17-O-HexCl | 81,800/0.3mg | >95% | 0 |
| 08472 |  | CC-PEG16-O-HexCl | 81,800/0.3mg | >95% | 0 |
| 08471 |  | CC-PEG15-O-HexCl | 81,800/0.3mg | >95% | 0 |
| 08470 |  | CC-PEG14-O-HexCl | 81,800/0.3mg | >95% | 0 |
| 08469 |  | CC-PEG13-O-HexCl | 81,800/0.3mg | >95% | 0 |
| 08468 |  | CC-PEG12-O-HexCl | 79,500/0.5mg | >95% | 0 |
| 08467 |  | CC-PEG11-O-HexCl | 81,800/0.3mg | >95% | 0 |
| 08466 |  | CC-PEG10-O-HexCl | 81,800/0.3mg | >95% | 0 |
| 08465 |  | CC-PEG9-O-HexCl | 82,300/10mg | >95% | 0 |
| 08464 |  | CC-PEG8-O-HexCl | 82,300/10mg | >95% | 0 |
| 08463 |  | CC-PEG7-O-HexCl | 82,300/2.5mg | >95% | 0 |
| 08462 |  | CC-PEG6-O-HexCl | 82,300/2.5mg | >95% | 0 |
| 08461 |  | CC-PEG5-O-HexCl | 82,300/2.5mg | >95% | 0 |
| 08460 |  | CC-PEG4-O-HexCl | 85,400/50mg | >95% | 0 |
| 06680 |  | CC-PEG3-O-HexCl | 85,400/50mg | >95% | 0 |
| 06681 |  | CC-PEG2-O-HexCl | 82,300/5mg | >95% | 0 |
| 06682 |  | CC-PEG1-O-HexCl | 82,300/10mg | >95% | 0 |
We also have extensive experience in synthesising halo-tagged fluorescent dyes.
| SCHEM No. | Structure | Compound Name | Price (JPY) | Purity | Stock(mg) |
|---|---|---|---|---|---|
| 05373 |  | Cy5(1-Pr-SO3H 5-SO3H 8-Me 8-Hex-CONH-PEG13-CONH-PEG2-Hex-Cl 1'-Pr-SO3H 5'-SO3H 8',8'-diMe) | 133,800/0.1mg | >90% | 0.1 |
| 04746 |  | CF660R-PEG13-PEG2-O-HexCl | 133,800/0.1mg | >95% | 0.1 |
| 02819 |  | CR110-Halolinker | 69,600/0.1mg | >95% | 0.3 |
| 01979 |  | BODIPY halolinker | 106,300/0.1mg | >95% | 0.3 |
| 01980 |  | Cy3-halolinker | 64,200/0.2mg | >95% | 0.1 |
In addition to the list above, we have many other synthesis results. The synthesis method has been established, so it can be synthesised in about a week by reacting with inexpensive commercially available fluorescent dyes.
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