Synthesis of double-ended SH polyethylene glycol.

We have established a method for the synthesis of PEG with double-ended SH (SH-PEGn-SH).

Derived from both terminal tosylates to thiols in a two-step process.

Due to stability problems (easily oxidised in air) and a strong odour depending on the reagents used, the synthesis of thiols requires a unique technique.
Methods for the synthesis and purification of double-ended thiol-PEGs of various lengths have been established after much struggle.


SCHEM No. Structure Compound Name Price (JPY) Purity Stock(mg)
06363

SH-PEG12-SH

75,000/2.5mg>90%0
06362

SH-PEG11-SH

71,500/0.2mg>90%0
06361

SH-PEG10-SH

68,400/0.4mg>90%0
01724

SH-PEG9-SH

75,000/2.5mg>90%44.3
06360

SH-PEG8-SH

88,400/2.5mg>90%0
06359

SH-PEG7-SH

80,100/0.7mg>90%0
01794

SH-PEG6-SH

64,000/0.7mg>90%0
06357

SH-PEG5-SH

64,000/0.7mg>90%0
04712

SH-PEG4-SH

inquire>90%60.0
06358

SH-PEG3-SH

inquire>90%1.3



Can be derived from SH-PEGn-SH to the following. :dimer by disulfide bonding.

Can be utilised as a covalent linker with Michael addition via SH.DISULFIDE bonds can be cleaved with mild reducing agents such as DTT.




SCHEM No. Structure Compound Name Price (JPY) Purity Stock(mg)
06340

SH-PEG4-SS-PEG4-SH

84,100/0.7mg>90%34.0
06341

SH-PEG3-SS-PEG3-SH

84,100/0.7mg>90%0

Oxidation of the SH-PEGn-SH structure forms cyclic disulphides.

SCHEM No. Structure Compound Name Price (JPY) Purity Stock(mg)
06354

Cyclic(-S-PEG12-S-)

71,500/0.1mg>95%0
06384

Cyclic(-S-PEG4-S-)9

149,100/0.1mg>95%0.1
06383

Cyclic(-S-PEG4-S-)8

149,100/0.1mg>90%0.1
06382

Cyclic(-S-PEG4-S-)7

149,100/0.1mg>90%0.1
06381

Cyclic(-S-PEG4-S-)6

149,100/0.1mg>90%0.1
06380

Cyclic(-S-PEG4-S-)5

149,100/0.1mg>90%0.1
06379

Cyclic(-S-PEG4-S-)4

149,100/0.1mg>90%0.1
06378

Cyclic(-S-PEG4-S-)3

149,100/0.1mg>90%0.1
06353

Cyclic(-S-PEG4-S-)4

83,800/0.1mg>95%0
06352

Cyclic(-S-PEG4-S-)3

83,800/0.1mg>95%0
06343

Cyclic(-S-PEG4-S-)2

149,100/0.1mg>95%0.1
06342

Cyclic(-S-PEG3-S-)2

84,900/0.1mg>95%0

Cyclic thioethers can be synthesised from SH-PEGn-OH.h5> 
SCHEM No. Structure Compound Name Price (JPY) Purity Stock(mg)
06356

Cyclic(-S-PEG10-)

84,900/0.1mg>95%0
06355

Cyclic(-S-PEG4-S-PEG6-)

84,900/0.1mg>95%0
06375

Cyclic(-S-PEG9-)

84,900/0.1mg>95%3.5
06349

Cyclic(-S-PEG5-S-PEG3-)

84,900/0.1mg>95%0
06350

Cyclic(-S-PEG7-S-PEG1-)

84,900/0.1mg>95%0
06377

Cyclic(-S-PEG5-)

84,900/0.1mg>95%0
06351

Cyclic(-S-PEG3-S-PEG1-)2

84,900/0.1mg>95%0
06346

Cyclic(-S-PEG3-S-CH2-O-CH2-)2

84,900/0.1mg>95%0

N-containing crown ethers (aza-crown) have also been synthesised.


Aza-crowns can be synthesised from NH2-PEGn-OH.

We have only synthesised one azacrown because the size of the market is unknown, but we have already established a synthetic method and many of the intermediates of each length are in stock, so if you contact us, we can synthesise an azacrown of the size you require within two weeks.


SCHEM No. Structure Compound Name Price (JPY) Purity Stock(mg)
06451

Cyclic(-NH-PEG14-)

97,200/0.1mg>90%0
06452

Cyclic(-NH-PEG13-)

84,900/0.1mg>90%0
06507

Cyclic(-NH-PEG12-)

84,900/0.1mg>90%0
06506

Cyclic(-NH-PEG11-)

84,900/0.1mg>90%0
06457

Cyclic(-PEG4-N-)-CO-PEG11-COOH

71,500/0.1mg>95%13.3
06505

Cyclic(-NH-PEG10-)

84,900/0.1mg>90%0
06504

Cyclic(-NH-PEG9-)

84,900/0.1mg>90%0
06503

Cyclic(-NH-PEG8-)

84,900/0.1mg>90%0
06502

Cyclic(-NH-PEG7-)

84,900/0.1mg>90%0
06501

Cyclic(-NH-PEG6-)

84,900/0.1mg>90%0
06376

Cyclic(-NH-PEG5-)

80,100/0.7mg>90%6.0
06385

Cyclic(-NH-PEG4-)

inquire>90%0
06388

Cyclic(-NH-PEG3-)

101,000/0.1mg>90%0


It is also possible to synthesise branched azacrowns via amide bonds or alkyl groups. These have not yet been synthesised, but the derivation from azacrowns is straightforward and ready to use.

Click here for a list of crown ethers with branches without N.

Limited to what is technically possible, e.g. length of PEG chain, substitution to heteroatoms other than O, number of substitutions, etc., but feel free to ask anything!

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